Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Charlie and Dan have been best friends and business partners for thirty years; their Manhattan public relations firm is on the verge of a huge business deal with a Japanese company. With two weeks to sew up the contract, Dan gets a surprise: a woman he married on a drunken impulse nearly nine years before (annulled the next day) shows up to tell him he's the father of her twins, now seven, and she'll be in jail for 14 days for a political protest. Dan volunteers to keep the tykes, although he's up tight and clueless. With Charlie's help is there any way they can be dad and uncle, meet the kids' expectations, and still land the account?