Christmas Blood is a thriller-slasher about a feared serial killer, called Nissen, who has struck Norway's countryside every Christmas Eve for over 13 years. Investigators Rasch and Hansen is trying to solve the riddle before he returns. This time it appears that it is northern Norway that will face Nissen's bloodbath.

A mother reports her student daughter Lisa missing, but detective Aslak Eira is getting too little information, and she is found in a lake. The more they investigate, the less they seem to understand. Then Lisa's best friend goes missing too.