Can a girl from Little Rock find happiness with a mature French planter she got to know one enchanted evening away from the military hospital where she is a nurse? Or should she just wash that man out of her hair? Bloody Mary is the philosopher of the island and it's hard to believe she could be the mother of Liat who has captured the heart of Lt. Joseph Cable USMC. While waiting for action in the war in the South Pacific, sailors and nurses put on a musical comedy show. The war gets closer and the saga of Nellie Forbush and Emile de Becque becomes serious drama.

Former radio singer Kay learns from her gossipy friends that her husband, Steve, has had an affair with chorus girl Crystal. Devastated, Kay tries to ignore the information, but when Crystal performs one of her musical numbers at a charity benefit, she breaks down and goes to Reno to file for divorce. However, when she hears that gold-digging Crystal is making Steve unhappy, Kay resolves to get her husband back. The Opposite Sex is a remake of the 1939 comedy The Women.