Francis is desperate: her parents want to force her to come with them on vacation to Hawaii - just during the two weeks when her beloved "Moondoggy" is home from College. When he suggests her to go for it, she's even more in panic - doesn't he care to be with her? So she sets out for Hawaii in the worst mood. On the plane she meets the sociable Abby, who gives her the advice to forget about Jeff - and regrets it shortly after, when Francis follows the advice and steals her boyfriend Eddie, a famous dancer. But then Jeff discovers he's missing Francis...

Former radio singer Kay learns from her gossipy friends that her husband, Steve, has had an affair with chorus girl Crystal. Devastated, Kay tries to ignore the information, but when Crystal performs one of her musical numbers at a charity benefit, she breaks down and goes to Reno to file for divorce. However, when she hears that gold-digging Crystal is making Steve unhappy, Kay resolves to get her husband back. The Opposite Sex is a remake of the 1939 comedy The Women.

A crusading psychiatrist battles a sadistic female warden to improve conditions at a women's prison.