Sergio Benvenuti is a shy seller of contracts for a Roman company of music, but because of his character he cannot find even a customer, so he asks for help from a fellow named Nadia.

Jack Beauregard, an ageing gunman of the Old West, only wants to retire in peace and move to Europe. But a young gunfighter, known as "Nobody", who idolizes Beauregard, wants him to go out in a blaze of glory. So he arranges for Jack to face the 150-man gang known as The Wild Bunch and earn his place in history.

As the railroad builders advance unstoppably through the Arizona desert on their way to the sea, Jill arrives in the small town of Flagstone with the intention of starting a new life.

While the Civil War rages on between the Union and the Confederacy, three men – a quiet loner, a ruthless hitman, and a Mexican bandit – comb the American Southwest in search of a strongbox containing $200,000 in stolen gold.

Two bounty hunters are in pursuit of "El Indio," one of the most wanted fugitives in the western territories, and his gang.