Harry is a retired teacher in his 70s living in the Upper West Side of New York City where his late wife and he raised his children--where he's lived all his life. When the building he lives in is torn down to make way for a parking garage, Harry and his beloved cat Tonto begin a journey across the United States, visiting his children, seeing a world he never seemed to have the time to see before, making new friends, and saying goodbye to old friends.

Julie Messinger is an intense woman who hides her wild emotions and desires under her conventional facade. Her husband Richard checks into the hospital for a simple mole removal that goes seriously wrong.

Dr. Bock, the chief of medicine at a Manhattan hospital, is suicidal after the collapse of his personal life. When an intern is found dead in a hospital bed, it appears to Bock to be a case of unforgivable malpractice. Hours later, another doctor, who happens to be responsible for another case of malpractice, is found dead. Despondent, Bock finds himself drawn to Barbara, the daughter of a comatose missionary.