When an IMF mission ends badly, the world is faced with dire consequences. As Ethan Hunt takes it upon himself to fulfill his original briefing, the CIA begin to question his loyalty and his motives. The IMF team find themselves in a race against time, hunted by assassins while trying to prevent a global catastrophe.

Sir Arthur Conan Doyle, Harry Houdini and Stratton are tasked with the cases that nobody else can solve. It challenges their sense of what is real and what is not. Houdini is a skeptic, while Doyle believes in the unseen. Their diverse viewpoints make solving crime a challenge and often Stratton is put in the middle. The trio will take on cases that involve vampires, ghosts, monsters and poltergeists…or are they a ruse to conceal murder?