Luna Kunath (Caroline Erikson) and Tamara Meurer (Anjua Pahl) work together in the Potsdam murder commission. Luna is single, strong, assertive, funny, empathic, sporty and fast in the head. It is an excellent policewoman whose carefree always accompanies with a little naivety and brings you again and again in brenzy situations. Tamara, however, has more mature, adult. The two of the boss Bernhard Henschel (Michael Lott) and the colleagues David Grünbaum (Omar El-Saeidi), Christoph Westermann (Hendrik von Bültzingslöwen), lail-sure Thomas Brandner (Yung No) and legal physician Werner Vense (Bernd Stegemann). Potsdam, Berlin's pretty little sister, confronts the commissars again and again with a wide variety of life effects. However, the team not only determines in Potsdam, but must always be out of the surrounding area. Because the crime does not stop at the city limit.

Nurse Vera (Rebecca Immanuel) seeks a new professional beginning. Together with her 16 year old son Paul (Tom Böttcher) and 8 year old daughter Mia (Mascha Schrader), the single mother moves from Berlin into the Eifel. But already on her first day of work at the office of her new boss Dr. Chris Wegner (Simon Schwarz) sitting in a wheelchair, she has to find out how hard the business is in the country due to the lack of enough general practitioners available. A long list of home visits are awaiting Vera, who glances with professional experience and empathy for her patients, but time pressure doesn't help in serving her patients as desired.