A teenage girl discovers a box with magical powers, but those powers comes with a deadly price.

One cannot quench his all-consuming thirst. The other cannot tame the beast clawing its way out. In the sleepy Pennsylvania village of Hemlock Grove, two young men struggle to accept painful truths: about family, themselves, the mystery of the White Tower - and a terrifying new threat so powerful it will turn them from predators into prey.

Rose, a desperate mother takes her adopted daughter, Sharon, to the town of Silent Hill in an attempt to cure her of her ailment. After a violent car crash, Sharon disappears and Rose begins a desperate search to get her back. She descends into the center of the twisted reality of a town's terrible secret. Pursued by grotesquely deformed creatures and townspeople stuck in permanent purgatory, Rose begins to uncover the truth behind the apocalyptic disaster that burned the town 30 years earlier.