After years of separation, Irena Gallier and her minister brother, Paul, reunite in New Orleans. When zoologists capture a wild panther, Irena is drawn to the cat – and zoo curator Oliver to her. Soon, Paul will have to reveal the family secret: that when sexually aroused, they revert into predatory jungle cats.

After several locals are viciously murdered, a Louisiana sheriff starts to suspect he may be dealing with a werewolf.