Dr. Daniel Pierce, a neuroscientist and professor, is recruited to help the federal government crack difficult cases. His intimate knowledge of human behavior and masterful understanding of the mind give him an extraordinary ability to read people, but his eccentric view of the world and less-than-stellar social skills can often interfere with his work.

After the patriarch of the Disguisey family is kidnapped by Devlin Bowman in an attempt to steal the most precious treasures from around the world, Italian waiter Pistachio Disguisey utilizes his supernatural ability to disguise himself in an attempt to stop him.