International spies Napoleon Solo (Robert Vaughn) and Illya Kuryakin (David McCallum) travel around the globe in an effort to track down a secret formula that was divided into four parts and left by a dying scientist with his four of five daughters, all of whom live in different countries. His widow, Amanda, is murdered at the beginning by the counter-spies of the organization THRUSH. Evil THRUSH agent Randolph also wants the formula, and is aided by his karate-chopping henchmen.

A young girl is killed at the beach in Malibu. Professor Otto Lindsay suspects that it is some form of mutated fish. However, his son Richard, who was a good friend of the girl, thinks that it is a madman who has a grudge against Richard and his friends. Soon the list of victims grows.

The Dick Van Dyke Show centers around the work and home life of television comedy writer Rob Petrie. The plots generally revolve around problems at work, where Rob got into various comedic jams with fellow writers Buddy Sorrell, Sally Rogers and producer Mel Cooley.