Dr. Abe Mandelbaum has just moved into a retirement home. After forming an unlikely friendship with a womanizing gambler, their relationship is tested when they each try to convince a mysterious nurse that they are her long-lost father.

A crime she committed in her youthful past sends Piper Chapman to a women's prison, where she trades her comfortable New York life for one of unexpected camaraderie and conflict in an eccentric group of fellow inmates.