Michael Long, an undercover police officer, is shot while investigating a case and left for dead by his assailants. He is rescued by Wilton Knight, a wealthy, dying millionaire and inventor who arranges life-saving surgery, including a new face and a new identity--that of Michael Knight. Michael is then given a special computerized and indestructible car called the Knight Industries Two Thousand (nicknamed KITT), and a mission: apprehend criminals who are beyond the reach of the law. The series depicts Michael's exploits as he and KITT battle the forces of evil on behalf of the Foundation for Law and Government.

The "Missing Heart Murders" are plaguing San Francisco - dead bodies that turn up with their hears surgically removed! So a weak-stomached homicide cop looks into the possibilities of a black market for human organs, while across town a man must make a difficult decision regarding his wife, who needs a transplant...

Joe Pendleton is a quarterback preparing to lead his team to the superbowl when he is almost killed in an accident. An overanxious angel plucks him to heaven only to discover that he wasn't ready to die, and that his body has been cremated. A new body must be found, and that of a recently-murdered millionaire is chosen. His wife and accountant—the murderers—are confused by this development, as he buys the L.A. Rams in order to once again quarterback them into the Superbowl.