In New York City, detective Luigi Mackeroni investigates a string of mysterious penile mutilations at the Hotel Quickie. After Mackeroni attempts to have a tryst with a gigolo he meets in the lobby, a carniverous condom bites off his right testicle and flees, which sets the detective off on a quest to stop the predatory prophylactic once and for all.

Sabine works in a hairdressing salon in Berlin. In order to keep the job, she has to occasionally grab the boss. She also feeds her boyfriend Frank. Sabine has simple dreams: sleek-cars and holidays on the beach.