A boy named Eli with a rare autoimmune disorder is confined to a special experimental clinic for his treatment. He soon begins experiencing supernatural forces, turning the supposedly safe facility into a haunted prison for him and his fellow patients.

A preacher sets out on a mission to make the almighty himself confess his sin of abandoning the world. With his best friend Cassidy, an alcoholic Irish vampire, his love Tulip, a red blooded gun towing Texan, and the power of genesis, an unholy child born from an angel and a devil, Jesse gives up everything to set the world straight with its creator.

The story of a mild-mannered radio executive who strives to become the best stepdad ever to his wife's two children, but complications ensue when their freewheeling, freeloading real father arrives, forcing stepdad to compete for the affection of the kids.