Millionaire Mason Murphy renovates the haunted Mayhew mansion. He plans a tremendous lunar eclipse viewing party to celebrate his return to his hometown of River Ridge Iowa. At the party, magic runs out of control and the party guests are murdered one by one.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.