John Netherwood and his wife Leann are fugitives who are both wanted for murder. They have a young daughter named Janie and they want her back.

Just retired from the Drug Enforcement Agency, John Hatcher returns to his hometown and quickly discovers that drugs have infiltrated his old neighborhood. Determined to drive the dealers out, Hatcher crosses paths with a ferocious Jamaican drug lord who vows that Hatcher and his family are now marked for death.

A St. Louis cop, Mike Braxton (Sam Jones), receives an urgent call for help from his brother Tony (Nick Cassavetes), a small time thief in Los Angeles. Mike rushes to LA and finds that his brother has been murdered and his brother Tony's girlfriend gunned down right in front of him. Mike quickly learns Tony was a courier for an arms smuggler, Simon Stone (John Russell). When Mike meets Stone's lawyer, Samantha Richardson (Vanessa Williams), the two team up to bring down Stone's arms smuggling empire. However, Mike's infatuation with Samantha keeps putting them in greater danger.

Deceased drifter Mike arrives in Heaven and quickly falls for newborn soul Annie, soon to start her assignment on Earth. When Annie leaves, Mike follows.

An aircraft crashes in the Florida Everglades, killing 103 passengers. After the wreckage is removed, salvageable parts from the plane are used to repair other aircraft. Soon passengers and crew on those aircraft report seeing what they believe to be the ghost of the wrecked airplane's flight engineer.