In this strange western version of Moby Dick, Wild Bill Hickok hunts a white buffalo he has seen in a dream. Hickok moves through a variety of uniquely authentic western locations - dim, filthy, makeshift taverns; freezing, slaughterhouse-like frontier towns and beautifully desolate high country - before improbably teaming up with a young Crazy Horse to pursue the creature.

A dabbler-in-crime and his assistant hire an ex-police reporter to recover some stolen papers.

In the depression, Chaney, a strong silent streetfighter, joins with Speed, a promoter of no-holds-barred street boxing bouts. They go to New Orleans where Speed borrows money to set up fights for Chaney, but Speed gambles away any winnings.