Hong Kong 97 takes place in Hong Kong right before the transfer of power from Britain to China. Reginald Cameron, an assassin affiliated with a large corporation with interests in the colony, guns down key members of the Chinese envoy which will take charge of Hong Kong the next day. Suddenly, he becomes a target for every two-bit mercenary in the city. With the help of his company mentor, a clueless friend, and his ex-girlfriend, Cameron must unravel the motives behind his sudden target status and escape Hong Kong alive.

Vilma Santos and Christopher De Leon portray two star crossed lovers, meeting each other across several lifetimes, hoping that in each cycle they can break down the walls that keep them apart.