Annie (Ann Gillis), an orphan, (based on Harold Gray's comic strip but who is at no point in the film called 'Little Orphan Annie), is befriended by a fight manager, 'Pop' Corrigan (J. Farrell MacDonald). She brings him Johnny Adams (Robert Kent), a promising prizefighter. Annie gets the people of the neighborhood to finance his training. But on the night of Johnny's big fight, a gambling syndicate locks him in a gymnasium and it appears the neighborhood folks will lose their investment.

A wealthy woman's wild lifestyle finally drives her husband to take their two children, move out of the house and file for divorce. Positive she'll lose her children unless she shows the judge that she's changed her wild ways, she takes in two poor street kids, a brother and sister.