Duncan MacLeod cannot die -- he is a 400-year-old immortal, who has seen his share of humanity's history. Still, he risks his life in battle against other immortals and tries to save people from harm.

Orpheus is a rock star who composes love songs for Eurydice, who designs his album covers. As he wrestles with his additional love for Calaïs, his sound engineer, Orpheus finds that Eurydice had died of a drug overdose, so he descends into the Underworld to try and make a deal with Hades.