An exploration of the United States of America's war on drugs from multiple perspectives. For the new head of the Office of National Drug Control Policy, the war becomes personal when he discovers his well-educated daughter is abusing cocaine within their comfortable suburban home. In Mexico, a flawed, but noble policeman agrees to testify against a powerful general in league with a cartel, and in San Diego, a drug kingpin's sheltered trophy wife must learn her husband's ruthless business after he is arrested, endangering her luxurious lifestyle.

The vampire Angel, cursed with a soul, moves to Los Angeles and aids people with supernatural-related problems while questing for his own redemption. A spin-off from Buffy the Vampire Slayer.

Cosmo, an affectless mob bookie who lives in the basement of a retirement home, is promoted to hitman. He learns his new trade from Steve, a seasoned killer. He falls in love with a yoga teacher, Jasmine, and must figure out a way to leave the mob so they can be together.

Topper Harley is found to be working as an odd-job-man in a monastery. The CIA want him to lead a rescue mission into Iraq, to rescue the last rescue team, who went in to rescue the last rescue team—who went in to rescue hostages left behind after Desert Storm.