Trey Parker and Matt Stone celebrate South Park's 25th anniversary with a concert in Colorado, featuring Primus and Ween.

When the four boys see an R-rated movie featuring Canadians Terrance and Philip, they are pronounced "corrupted", and their parents pressure the United States to wage war against Canada.

Two losers from Milwaukee, Coop and Remer, invent a new game playing basketball, using baseball rules. When the game becomes a huge success, they, along with a billionaire's help, form the Professional Baseketball League where everyone gets the same pay and no team can change cities. Theirs is the only team standing in the way of major rule changes that the owner of a rival team wants to institute.

Follows the misadventures of four irreverent grade-schoolers in the quiet, dysfunctional town of South Park, Colorado.