Russell Hatch, an Interpol operative who takes on the role of father figure to Jayden, the son of an informant killed in a routine raid gone wrong. Years later, Hatch finds himself protecting Jayden and his uncle from a group of merciless gangs in an all-out turf war, stopping at nothing to protect Jayden and fight anyone getting in his way. Including supposed allies with hidden agendas and nefarious intents.

One year after the events of "Kickboxer: Vengeance", Kurt Sloan has vowed never to return to Thailand. However, while gearing up for a MMA title shot, he finds himself sedated and forced back into Thailand, this time in prison. He is there because the ones responsible want him to face a 6'8" 400 lbs. beast named Mongkut and in return for the fight, Kurt will get two million dollars and his freedom back. Kurt at first refuses, in which a bounty is placed on his head as a way to force him to face Mongkut. Kurt soon learns he will have no other choice and will undergo his most rigorous training yet under some unexpected mentors in order to face Mongkut in hopes to regain his freedom.

Phillip and Suzanne are retired from the spy game, living peacefully off the grid. That's until their whereabout are discovered by Vlad the vengeful brother of their target from the first film.