After having strange dreams, Jenny Cole discovers that in her last incarnation she was Mary Sutton, an Irishwoman who died in the 1930s. Suspicious, Jenny goes to Ireland to investigate her past life.

When her doctor recommends that a widow pursue her unfulfilled life ambitions, he doesn't realize that she has always wanted to be a spy. Sending a letter to her congressman gets her an interview with the CIA and accidentally gets her an assignment to Morocco for a supposed easy task of picking up an encrypted code book. When the agency realizes their mistake, they send a super-agent to watch over her. Both are taken prisoner and the real agent is injured, leaving Mrs. Pollifax to use her considerable wits to help them escape and to save the day.

Walt Disney Productions (later The Walt Disney Company) has produced an anthology television series under several different titles since 1954. The original version of the series premiered on ABC in 1954. The show was broadcast weekly on one of the Big Three television networks until 1990, a 36-year span with only a two-year hiatus in 1984-85. The series was broadcast on Sunday for 25 of those years. From 1991 until 1997, the series aired infrequently. The program resumed a regular schedule in 1997 on the ABC fall schedule, coinciding with Disney's recent purchase of the network. From 1997 until 2008, the program aired regularly on ABC. Subsequently, ABC continued the series as an occasional special presentation.

During World War 1, the young Boudreau sisters decide to aid the war effort by catching spies. The strange activities of Nobel-Prize winning scientist Marie Curie make her a prime suspect. When the girls follow Curie to the battlefront, they witness her fight to use science and her X-ray machine to save the lives of the wounded, including their father.