As the Roman empire crumbles, young Romulus Augustus flees the city and embarks on a perilous voyage to Britain to track down a legion of supporters.

As a young boy, future emperor Nero witnesses the mad Emperor Caligula kill his father and exile his mother. While in exile in the pontine islands, Agrippina, his mother, sees a vision telling her that her son can become emperor, but she will have to die first. She accepts the proposal. Back in Rome, Nero, now being raised by emperor Claudius after Caligula's death, Agrippina returns. She poisons Claudius' food and Nero becomes emperor. At first, Nero cuts taxes and introduces successful programs and invades Brittania. Soon he meets a beautiful slave named Claudia Acte, and marries her, throwing off his engagement with Claudius' daughter, Claudia Octavia, telling her she can marry someone she will be happy with. Heartbroken, she arrives at an island and kills herself. Nero enjoys being married to Claudia Acte, but soon he gradually goes mad with power and sets fire to Rome.

Jerri Blank is a former prostitute and junkie whore who returns to high school as a 46-year-old freshman at Flatpoint High. Jerri ran away from home and became 'a boozer, a user, and a loser' after dropping out as a teenager, supporting her drug habits through prostitution, stripping, and larceny. She has been to prison several times, the last time because she 'stole the TV'. At home, Jerri's father Guy is comatose, although he seems perfectly capable of amazing feats. Her stepmother Sara is vain and bitter, and stepbrother Derrick is a bullying jock. Jerri tries to do things the right way but always ends up learning the wrong lesson. Her hijinks often involve, either directly or indirectly, neurotic history teacher Chuck Noblet and his secret lover, sensitive art teacher Geoffrey Jellineck.