In New York, a Pakistani native finds that his American Dream has collapsed in the wake of the 9/11 terrorist attacks.

As an epidemic of a lethal airborne virus - that kills within days - rapidly grows, the worldwide medical community races to find a cure and control the panic that spreads faster than the virus itself.

Dave is a married man with two kids and a loving wife, and Mitch is a single man who is at the prime of his sexual life. One fateful night while Mitch and Dave are peeing in a fountain when lightning strikes, they switch bodies.