Alexander's day begins with gum stuck in his hair, followed by more calamities. Though he finds little sympathy from his family and begins to wonder if bad things only happen to him, his mom, dad, brother, and sister all find themselves living through their own terrible, horrible, no good, very bad day.

While romancing Palmer, a much younger schoolteacher, plastic surgeon Danny Maccabee enlists his loyal assistant Katherine to pretend to be his soon to be ex-wife, in order to cover up a careless lie. When more lies backfire, Katherine's kids become involved, and everyone heads off for a weekend in Hawaii that will change all their lives.

It has taken 10 years, two little Fockers with wife Pam and countless hurdles for Greg to finally get in with his tightly wound father-in-law, Jack. After the cash-strapped dad takes a job moonlighting for a drug company, Jack's suspicions about his favorite male nurse come roaring back. When Greg and Pam's entire clan descends for the twins' birthday party, Greg must prove to the skeptical Jack that he's fully capable as the man of the house.

Brad and Kate have made something of an art form out of avoiding their families during the holidays, but this year their foolproof plan is about go bust -- big time. Stuck at the city airport after all departing flights are canceled, the couple is embarrassed to see their ruse exposed to the world by an overzealous television reporter. Now, Brad and Kate are left with precious little choice other than to swallow their pride and suffer the rounds.

When petty criminal Earl Hickey wins the lottery, he sets off on a quest to repair his questionable karma.