Young lovers — she's a child of the ghetto, determined to escape her alcoholic, bickering parents; he's a socially prominent attorney with a long-standing health problem — attempt to defy every obstacle to their romance and ultimate marriage.

In New York City, bright but naive New Englander Anne Welles becomes a secretary at a theatrical law firm, where she falls in love with attorney Lyon Burke. Anne befriends up-and-coming singer Neely O'Hara, whose dynamic talent threatens aging star Helen Lawson and beautiful but talentless actress Jennifer North. The women experience success and failure in love and work, leading to heartbreak, addiction and tragedy.

This musical reworking of Too Many Husbands (1940), features Grable as a top singer and dancer who's been widowed by WW II. She marries her late husband's songwriting partner, Gower Champion, but the new marriage is thrown for a loop when Lemmon, her first husband, turns up very much alive and eager to see Grable.

Lorelei Lee is a beautiful showgirl engaged to be married to the wealthy Gus Esmond, much to the disapproval of Gus' rich father, Esmond Sr., who thinks that Lorelei is just after his money. When Lorelei goes on a cruise accompanied only by her best friend, Dorothy Shaw, Esmond Sr. hires Ernie Malone, a private detective, to follow her and report any questionable behavior that would disqualify her from the marriage.

An American joins the British Royal Air Force just before Pearl Harbor is attacked, and falls in love with a beautiful English girl.