Ricky Caldwell, the notorious 'Killer Santa Claus', awakens from a six-year coma after being kept alive on life-support by a slightly crazed doctor experimenting with ESP and other special abilities. Ricky targets a young, clairvoyant blind woman, named Laura, whom is traveling with her brother Chris, and his girlfriend Jerri to their grandmother's house for Christmas Eve, and Ricky decides to go after her, leaving a trail of dead bodies in his wake.

A mad scientist unleashes his master plan: to transform himself into a mutated walking catfish, and gain revenge on those who have spurned him. His plans go wrong, and he becomes tempted to kidnap a nubile young woman to similarly transform her so that he can breed.