Llewelyn Moss stumbles upon dead bodies, $2 million and a hoard of heroin in a Texas desert, but methodical killer Anton Chigurh comes looking for it, with local sheriff Ed Tom Bell hot on his trail. The roles of prey and predator blur as the violent pursuit of money and justice collide.

A killer is on the loose, and an FBI agent sifts through clues and learns that the bloodthirsty felon's victims of choice are other serial killers.