One day at work, unsuccessful puppeteer Craig finds a portal into the head of actor John Malkovich. The portal soon becomes a passion for anybody who enters its mad and controlling world of overtaking another human body.

A small, seemingly innocuous plastic reel of film leads surveillance specialist Tom Welles down an increasingly dark and frightening path. With the help of the streetwise Max, he relentlessly follows a bizarre trail of evidence to determine the fate of a complete stranger. As his work turns into obsession, he drifts farther and farther away from his wife, family and simple life as a small-town PI.

Scott, John and Suzie quit their boring jobs and depart L.A. for Alaska to pursue their dream of their own salmon fishing business. They soon find that life in Alaska is more difficult than expected as they are forced to abandon their plans and make desperate choices just to survive.