"Guy in Row Five" is a comedy about a dreamer named Thess who moves to Hollywood to become a star. He lands a job as an extra on the hit TV series "Rodeo Nights". After pestering his way in to an audition for the show's new series regular, he is so convinced that he booked the role that he decides to document his last day of being a struggling actor.

One day at work, unsuccessful puppeteer Craig finds a portal into the head of actor John Malkovich. The portal soon becomes a passion for anybody who enters its mad and controlling world of overtaking another human body.

When deadly terrorists strike, an FBI man, who is an expert on terrorist mentality, hunts their twisted "creator," who may be connected with a disgraced professor from his past.