A caucasian prospective grad student's affluent family won't pay his way through law school, so he takes tanning pills to darken his skin in order to qualify for an African-American scholarship at Harvard. He soon gets more than he bargained for, as he begins to learn what life is really like for blacks in America.

A group of varied misfits (including a former prostitute/stripper and a bumbler who can't see more than 6 inches in front of his face) enter a school to become flight attendants. Somehow, the group makes it through to the final test: a cross-country flight.

Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.

In Africa, a deceased medical missionary's daughter in Africa carries on her father's work. Before long, she finds herself in danger from crooks and a local witch doctor.