In New York City, detective Luigi Mackeroni investigates a string of mysterious penile mutilations at the Hotel Quickie. After Mackeroni attempts to have a tryst with a gigolo he meets in the lobby, a carniverous condom bites off his right testicle and flees, which sets the detective off on a quest to stop the predatory prophylactic once and for all.

Damiel is now married to Marion, runs the pizzeria “Da Angelo” and the two have a child. The solitarily remaining angel Cassiel is more and more dissatisfied with his destiny as a mere observer of human life and finally decides to take the great leap. As Karl Engel he soon gets into a dubious milieu and finds himself as the assistant of the German American Baker, who makes his money with shady arms deals and sends films east in exchange for weapons. Cassiel’s adventure turns into a “thriller” when he decides to put a stop to Baker’s game.