When a young rancher crosses paths with a Lakota girl from a nearby reservation, her mysterious disappearance sparks a search that uncovers a harrowing past and hints at a dire future.

When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.