Keef, an African-American cartoonist, is finally on the verge of mainstream success when an unexpected incident changes everything. He must now navigate the new voices and ideas that confront and challenge him, all without setting aflame everything he's already built.

Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

Gay detective Donald Strachey is commissioned to protect gay activist John Rutka, who is known for "outing" prominent citizens. Strachey abandons bodyguard duty when he feels that Rutka is staging the threats against himself. When Rutka turns up dead, Strachey is faced with an extensive list of enemies all with enough motive to kill.

A crook quietly plots his revenge against the boss who murdered his brother while working for him.