After Portland homicide detective Nick Burkhardt discovers he's descended from an elite line of criminal profilers known as "Grimms," he increasingly finds his responsibilities as a detective at odds with his new responsibilities as a Grimm.

Working-class father John Crowley is finally on the fast track to corporate success when his two young children are diagnosed with Pompe disease—a condition that prevents the body from breaking down sugar. With the support of his wife, John ditches his career and teams with unconventional specialist, Dr. Robert Stonehill to found a bio-tech company and develop a cure in time to save the lives of his children. As Dr. Stonehill works tirelessly to prove the theories that made him the black sheep of the medical community, a powerful bond is forged between the two unlikely allies.