An astronaut returns home from a year long solo mission in space. She tries to reconnect with her husband and son in their everyday life. Her experiences in space and home lead to events that ultimately will change the course of human history.

Murder in the First follows homicide detectives Terry English and Hildy Mulligan as they investigate a multitude of tragedies in San Francisco.

With the world now aware of his dual life as the armored superhero Iron Man, billionaire inventor Tony Stark faces pressure from the government, the press and the public to share his technology with the military. Unwilling to let go of his invention, Stark, with Pepper Potts and James 'Rhodey' Rhodes at his side, must forge new alliances – and confront powerful enemies.

Rizwan Khan, a Muslim from the Borivali section of Mumbai, has Asperger's syndrome. He marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who treat him as a terrorist because of his condition and his race.

When Buy More computer geek Chuck Bartowski unwittingly downloads a database of government information and deadly fighting skills into his head, he becomes the CIA's most vital secret. This sets Chuck on a path to become a full-fledged spy.

Grace Hanadarko is a tormented, fast-living Oklahoma City police detective who, despite having an excellent career in solving crimes, takes self-destruction to new heights. After seeing tremendous tragedy, both professionally and personally, Grace reaches a turning point one night and meets a rough-hewn angel with a similar past who wants to help lead her back to the right path.

Las Vegas showroom magician Cris Johnson has a secret which torments him: he can see a few minutes into the future. Sick of the examinations he underwent as a child and the interest of the government and medical establishment in his power, he lies low under an assumed name in Vegas, performing cheap tricks and living off small-time gambling "winnings." But when a terrorist group threatens to detonate a nuclear device in Los Angeles, government agent Callie Ferris must use all her wiles to capture Cris and convince him to help her stop the cataclysm.

An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.

While traveling through the cursed Old Highway 13 in New Mexico, each passenger of a bus to Las Vegas is attacked by an evil fiend that possesses and destroys their bodies.

Film star Vince Chase navigates the vapid terrain of Los Angeles with a close circle of friends and his trusty agent.