Megan, a Buffalo police officer suffering from PTSD, goes on a weekend camping trip with her partner Jeremy and his friends Blake and Gabriella. When Megan and Jeremy witness an execution by a rogue sheriff's department, the quartet finds itself hunted by different factions of an armed militia.

Marcus, a young man with a disability, is bullied and killed after a prank goes wrong. In the afterlife, he meets a group of ghostly clowns who help him exact revenge on those who have wronged him.

Mad scientist Prospero runs away with his blind daughter Miranda to Tromaville, hiding from evil pharmaceutical execs, including his own sister Antoinette who ruined his career after he found the cure against opioid addiction. With the help of a handicapped crack-whore, he releases a massive amount of laxative to whales, while his enemies are on a cruise ship to North Korea. A humongous shitstorm washes the boat away and brings them to Tromaville, where Prospero can now fully realize his ultimate vengeance.

Six people find themselves trapped in Love Canal, Niagara Falls, an old toxic waste site, and witness the first hours of the plague that brings the dead back to life.

"Diffability Hollywood is a documentary about Hollywood's portrayal of people with disabilities in films throughout history. One of filmmaker Adrian Esposito's main goals in making this film is to have people with disabilities portrayed in a less stereotypical way and to advocate for more inclusion of writers, directors and actors with disabilities into the movie industry.