The film chronicles the rise and fall of the world's most feared drug lord Pablo Escobar and his volatile love affair with Colombia's most famous journalist Virginia Vallejo throughout a reign of terror that tore a country apart.

The story of Hugh Knight, a rising heart surgeon who is gifted, charming and infallible. He is a hedonist who, due to his sheer talent, believes he can live outside the rules. His "work hard, play harder" philosophy is about to come back and bite him.

The lives of staff at the fictional Kings Cross Hospital and the wild streets of Darlinghurst in the 1960s. Joan Miller is a smart and sophisticated midwife who returns home from London to take a job at the Kings Cross Hospital. Dr Patrick McNaughton is a charismatic head of obstetrics at Kings Cross Hospital. Frances Bolton is the tough matron who also controls the running of Stanton House, a home for unwed pregnant young women.