After Portland homicide detective Nick Burkhardt discovers he's descended from an elite line of criminal profilers known as "Grimms," he increasingly finds his responsibilities as a detective at odds with his new responsibilities as a Grimm.

Fleeing the wrath of man-eating vixens who've taken over the world, a ragtag caravan of refugees makes its way across the country to the relative safety of the West Coast. But en route, they're attacked by unrelenting waves of starving strippers. If looks could kill ... well, let's just hope they can't.