After a fateful encounter in the summer of 1966, the lives of two brothers from a middle-class Roman family take different directions, intersecting with some of the most significant events of postwar Italian history in the following decades.

Depressed magistrate Damiano Fortezza relocates from Milan to a small town in Campania, where the three Fontana sisters, owners of a chain of incinerators, dominate. The youngest, Eugenia, is about to marry a well-known crook Fortezza has to prosecute. However, he ends up falling in love with Eugenia and questioning the priorities of his job.

June 27, 1980: a DC–9 flying over the Tyrrhenian Sea breaks up mid-air and crashes near the Italian island of Ustica, killing all 81 people on board. The official version blames the "structural failure" of the plane, but a young journalist smells a cover-up and starts fighting to break free the truth from the 'invisible wall' of lies built by politicians and air force higher-ups.

Tommaso Scalia is a man who commits three murders: he kills his superior who sacked him, the man who replaced him and his wife. He wants a quick trial and an early execution, but an earnest, principled assistant judge looks for a way to save the murderer from being shot, because he does not belive in capital punishment.

The enthusiasms, fears, joys and disappointments of the (private and professional) life of a well-known group of boys fond of physics and mathematics, who just made history as the Via Panisperna boys.