June 27, 1980: a DC–9 flying over the Tyrrhenian Sea breaks up mid-air and crashes near the Italian island of Ustica, killing all 81 people on board. The official version blames the "structural failure" of the plane, but a young journalist smells a cover-up and starts fighting to break free the truth from the 'invisible wall' of lies built by politicians and air force higher-ups.

This time the "amici" (friends) are just four: Necchi, Meandri, Mascetti and Sassaroli. Nevertheless they are older they still love to spend their time mainly organizing irresistible jokes to everyone in every kind of situation. Mascetti is hospitalized in a geriatric clinic. Of course the place become immediately the main stage for all their jokes. After some jokes they decided to place an ultimate incredible and farcical joke to the clinic guests.