A group of Iraq War veterans goes on the run from U.S. military forces while they try to clear their names after being framed for a crime they didn't commit. Along the way, Col. Hannibal Smith, Capt. H.M. ‘Howling Mad’ Murdock , Sgt. Bosco ‘B.A.’ Baracus, and Lt. Templeton ‘Faceman’ Peck help out various people they encounter.

When an author invites his friends to his home on a private island, the guests realize they've been poisoned at dinner. The only way to receive the antidote from their twisted host will be to confess to all the lies they've ever told.