Lisa Spinelli is a Staten Island teacher who is unusually devoted to her students. When she discovers one of her five-year-olds is a prodigy, she becomes fascinated with the boy, ultimately risking her family and freedom to nurture his talent.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

A former police officer and a journalist go on the hunt for a serial killer stalking New York City.