Born under unusual circumstances, Benjamin Button springs into being as an elderly man in a New Orleans nursing home and ages in reverse. Twelve years after his birth, he meets Daisy, a child who flits in and out of his life as she grows up to be a dancer. Though he has all sorts of unusual adventures over the course of his life, it is his relationship with Daisy, and the hope that they will come together at the right time, that drives Benjamin forward.

Katherine Morrissey, a former Christian missionary, lost her faith after the tragic deaths of her family. Now she applies her expertise to debunking religious phenomena. When a series of biblical plagues overrun a small town, Katherine arrives to prove that a supernatural force is not behind the occurrences, but soon finds that science cannot explain what is happening. Instead, she must regain her faith to combat the evil that waits in a Louisiana swamp.