Clara and Alejandro move into a new house. A few days later, he goes on a work trip and she is left alone, surrounded by moving boxes. That chaos makes her accept a series of random invitations that will take her away from the hermetic world she lives in.
Víctor Tellez is an intellectual, world-weary film critic who prefers to think in French and eschew the clichés of romantic movies...until he finds himself living a sappy, feel-good love story of his own.
Patagonia narrates the journeys of two women - one looking for her past, the other for her future. The film inter-cuts between their stories, in which one of them travels south to north through the Welsh springtime and the other east to west through the Argentine autumn.