Jill Conway is trying to rebuild her life after surviving a terrifying kidnapping attempt. Though she is having a difficult time, she takes small steps toward normalcy by starting a new job and inviting her sister, Molly, to move in with her. Returning home from work one morning, Jill discovers that Molly has vanished, and she is certain that the same man who previously abducted her has returned for revenge.

After Portland homicide detective Nick Burkhardt discovers he's descended from an elite line of criminal profilers known as "Grimms," he increasingly finds his responsibilities as a detective at odds with his new responsibilities as a Grimm.